The family of herpes viruses – a therapeutic challenge

Dr Sabine Rauch, MD, Specialist in General Medicine and Olle Svensson, Simlångsdalen, Sweden

8 human-pathogenic herpes viruses belonging to the Herpesviridae family are so far known:

Virus - Primary infection - Reactivation

Herpes simplex virus 1 (HHV 1) - Gingivostomatitis herpetica - Herpes labialis
Herpes simplex virus 2 (HHV 2) - Herpes genitalis - Herpes genitalis
Varicella zoster virus (VZV) (HHV 3) - Varicella (chickenpox) - Herpes zoster
Epstein-Barr virus (EBV) (HHV 4) - Infectious mononucleosis - Mononucleosis - like exanthema, lymphomas
Cytomegalovirus (CMV) (HHV 5) - Cytomegaly (newborns) Mononucleosis (adults) - Pneumonia in immunodeficient patients
HHV 6 - Three-day fever
HHV 7 - Pityriasis rosea
HHV 8 - Kaposi’s sarcoma, Non-Hodgkin lymphoma

1.1. Alpha herpes viruses

Herpes simplex viruses HHV 1, HHV 2, and varicella zoster virus (VZV) HHV 3
Membrane-enveloped DNA viruses that contain double-stranded DNA (dsDNA) and are easily t...

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