Clinical effect, safety and mechanisms of BICOM 2000 system to asthma in children

Feng Yi Zhen, Professor of pediatrics, Liu Li Ping, Wang Jin Rong,Shandong, China

Objectives
1. To examine the allergen detection, clinical effect, safety in the near future and side effects of the BICOM® 2000 system to asthma in children.
2. To explore the mechanism of BICOM® 2000 to asthma through evaluation of the changes in serum levels of IL-4, tIgE and IFN-gamma before and after BICOM® treatment.

Methods
1. Allergen detection and desensitization A total of 124 children with asthma and 150 children with asthma associated with rhinitis were selected according to the “national standard for child asthma” formulated by the national child asthma consortium. There were 82 mild, 164 moderate and 28 severe cases. All cases had not been treated with systemic glucocorticoids, antihistaminics or immunomodulators within one week before treatment. All children received allergen test and desensitization with BICOM®, together with the standard GINA therapy, which includes 125 microgra...

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