Hans Brügemann, Head of the Institute, Gräfelfing, nr. Munich
The phrase “level of evidence” is often used nowadays when attempting to prove the efficacy of drugs and medical devices. It describes the level of scientific proof and presence of meaningful data. The nature of this evidence is based on findings but more particularly on the construction of a scientific study, now also known as a “design”.
Various schemes have been proposed for classifying the level of evidence. We are using here the 8-level scheme of evidence according to the American Heart Association.
Classification of the levels of evidence according to the American Heart Association (AHA), modified according to W. F. Dick: Evidence based emergency medicine (abridged):
Level 1: Statistically significant, randomised, controlled trials (double-blind studies) or meta-analyses
Level 2: Statistically insignificant, randomised, controlled trials (double-blind studies) or meta-analyses
Level 3: Prospective, contr...